The Anti-Ageing Shop

What can you do for me resveratrol?

Resveratrol is an antioxidant substance last to market worldwide. Do you really deserve all the media attention it has aroused?

Resveratrol is a compound powerful antioxidant that may provide protection for a variety degenerative disorders. Studies have shown the many benefits of resveratrol for fat loss, cardiovascular health, reducing insulin resistance, Alzheimer's disease, anti-carcinogenic and anti-inflammatory effect. It has also been shown to extend lifespan in mammals by up to 15% (10 human years) by increasing the activity of sirtuins, which prolongs the life of living organisms.

This herbal anti-oxidant has been considered the "modern elixir of youth", scrub free radicals and prevent oxidative damage associated with aging. Some of these activities have been implicated in cardiovascular protective effects attributed to resveratrol and red wine.

Before 2002, there have been previous studies that describe the potential effects of resveratrol on the prolongation of life. However, in the last 5 years, several investigators have reported that resveratrol is a potent activator of enzyme activity sirtuins, mimics the beneficial effects of caloric restriction slows aging and increases longevity in a number of organisms.

In addition, Resveratrol appears to be effective in delaying the onset of a variety of age-related diseases in mammals such as rodents. Therefore, it is possible that resveratrol may play a role in extending the lifespan and can act as an anti-aging.

Resveratrol in high doses has been shown to prolong life some studies in invertebrates and to prevent early mortality in mice fed a high fat diet. In one U.S. study, researchers examined the effect a diet low doses of resveratrol and calorie restriction (CR), the lifespan of mice. They fed mice from middle-aged (14 months) to older (30 months) a control diet, a low dose of resveratrol, or a CR diet and examined genome-wide transcriptional profiles.

Researchers reported that an amazing coincidence of the transcript of the RC
resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibited gene expression profiles associated with aging, cardiac and skeletal muscle, and prevented age-related cardiac dysfunction. Resveratrol diet also mimics the effects of CR on glucose uptake mediated by insulin in muscle.

Gene expression profiling suggests that both CR and resveratrol could
delay some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be easily achieved in humans, as has been shown to meet the definition of a dietary compound that mimicked some aspects of CR and delayed some parameters of aging.

Resveratrol also has chemopreventive and chemotherapeutic properties and has been shown to increase life expectancy yeast and metazoans, including mice. Genetic evidence and measurements in vitro indicate that the Sir2/SIRT1 deacetylase enzyme, an enzyme promoting stress resistance and aging, is the target of resveratrol. Similarly, down-regulation of insulin-like pathways, including PI3K (phosphoinositide 3-kinase) mediates key, promotes longevity and is an attractive strategy to fight cancer.

In France, Fröjda S. et al demonstrated that resveratrol inhibits, in vitro and muscle cell lines, class IA PI3K and its downstream signaling in the same concentration range that activates sirtuins. Observations define class IA PI3K as a target of resveratrol that may contribute to longevity, promoting and anticancer properties and identified resveratrol as an inhibitor PI3K class-specific nature.

In the 1997 study reported in the journal Science, resveratrol was found to have greater inhibitory activity cancer initiation, promotion and progression. In particular, its antioxidant and anti-mutagenic potency and induction of phase II enzymes metabolizing drugs were seen as anti-carcinogenic initiation.

Resveratrol blocked cyclooxygenase and hydroperoxidase and initiated anti-inflammatory effects, demonstrating anti-promotion activity. Induction of differentiation of human promyelocytic leukemia cells by resveratrol thwarted progression of cancer activity. In addition, resveratrol has shown significant in vitro inhibitory effects induced by carcinogens with preneoplastic lesions in the glands mouse mammary and in vivo tumorigenesis in the two-stage skin cancer mouse model. The data suggest that resveratrol, a common component of the diet human, can be used as a cancer chemopreventive potential agent in humans.

Because of the lack of early diagnosis and therapeutic response poor median survival in patients with pancreatic cancer is less than 6 months, and survival beyond 5 years is rare. Therefore, a dimension novel chemotherapeutic agents for pancreatic cancer would be beneficial to control metastatic disease. The effect of resveratrol on cancer pancreas has been studied at Northwestern University Medical School in USA. The potential role of resveratrol was evaluated on the proliferation of cancer cells two human pancreatic cell lines of pancreatic cancer, PANC-1 and AsPC-1.

The results showed that resveratrol inhibits the proliferation of the PANC-1 and AsPC-1. The number of cells of the two cancer cell lines was significantly
decreased after treatment with resveratrol.

These findings suggest that resveratrol may have a potent antiproliferative effect on human pancreatic cancer with induction of apoptosis. Therefore, resveratrol is likely to be useful for management and prevention of human pancreatic cancer.

In an article published in the journal Nutrition, researchers Japanese found that resveratrol significantly reduced the tumor volume, tumor weight and lung metastases in mice bearing highly metastatic Lewis lung carcinoma (LLC) tumors. Furthermore, resveratrol inhibited DNA synthesis most strongly in LLC cells, increased apoptosis in CLL cells, and decreased the population of S phase Resveratrol inhibits tumor-induced neovascularization in vivo model. Moreover, resveratrol significantly inhibited the formation the formation of capillary tube as from umbilical vein endothelial cells (HUVEC), and binding of vascular endothelial growth factor (VEGF) in HUVEC.

The researchers suggest that the anti-tumor and anti-metastatic activities of resveratrol might be due to inhibition of DNA synthesis in LLC cells and induced inhibition of neovascularization LLC and tube formation (angiogenesis) of HUVECs by resveratrol.

Resveratrol has strong properties antioxidants have been associated with the protective effects of red wine consumption against coronary heart disease, which is commonly known as the "French paradox". In a study of Korea, Surh YJ Jang JH and investigated the effects of resveratrol on beta-amyloid-induced oxidative cell death in cultured rat pheochromocytoma (PC12) cells. There has been no hard evidence to support the idea that beta-amyloid-induced cytotoxicity is mediated through the generation of reactive oxygen intermediates (ROI).

PC12 cells treated with beta-amyloid showed increased accumulation of intracellular ROI and underwent apoptotic death. Beta-amyloid treatment also led to decreased mitochondrial membrane potential, the division of poly (ADP-ribose) polymerase, an increase in the ratio of Bax / Bcl-X (L) and
activation of c-Jun N-terminal kinase.

Resveratrol was found to attenuate the cytotoxicity, apoptosis and the formation of intracellular ROI. Polyphenols also frustrated other effects of beta-amyloid peptide, which is believed to account for the plaques that are characteristic of brain tissue in patients with Alzheimer's disease.

In India, Palsamy P. and S. Subramanian conducted a study to evaluate the antidiabetic properties of resveratrol in streptozotocin-nicotinamide induced diabetes experimental rats. Diabetic rats treated with resveratrol orally for 30 days resulted in a significant decrease in glucose levels in the blood, glycosylated hemoglobin, urea, uric acid, serum creatinine and decrease in activities of pathophysiological enzymes such as aspartate transaminases, alanine aminotransferase and alkaline phosphatase.

The anti-hyperglycemic nature of resveratrol evidenced by improved levels of plasma insulin and hemoglobin. Furthermore, the results are comparable with glyclazide, a standard oral antidiabetic medicine.

Therefore, these findings suggest that resveratrol may be considered as an effective therapeutic agent for the treatment of diabetes mellitus.

Many studies have shown that resveratrol has anti-inflammatory and has been attributed to have health benefits that help prevent cancer and heart disease. A treatment that combines anti-microbial and anti-inflammatory may be desirable for alleviating many skin conditions that vary in severity.

In summary shows a range of biological activities in the human body. These include anti-inflammatory, antioxidant, antitumor, anti-hyperglycemic, anti-cancer and antimicrobial properties. Resveratrol may also mimic the effects of the restriction heat and delay aspects of aging.

Along with the grape seed and red wine, resveratrol is a potent antioxidant boost, which helps protect the body against free radicals that are normally associated with premature aging and disease. It also supports a healthy cardiovascular and immune system optimal wellness. You can find all these ingredients in this product resveratrol.

About the Author

Leanne James is a Naturopath at Ideal Health. For more information visit Resveratrol

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