The Anti-Ageing Shop

Major Diseases of Aging global Unified theory: Easy, simple practices allow you to live longer and better

Major Diseases Aging global Unified theory: Easy, simple practices allow you to live longer and better.

Gregory S. Bambeck Ph.D. and Michael Wolfson JD, MBA from Kent, Ohio, USA 44240

INTRODUCTION

Even before the Human Genome Project, scientists have predicted a 'new was' of biomedicine. Myriad of small improvements continued to accumulate, but the great promises of fulfillment has arrived. For almost thirty years very exciting We have eagerly awaited a "breakthrough." Now the wait is over. This century, rightly, has been listed as the "century of biotechnology" and early fruits are finally ripening grapes.

One important genetic control system that manipulates found several thousand genes that regulate the metabolism of the fetus until the end of aging and even cancer cells, although with a special warning. From this control system regulation, we have gained a better understanding of the aging process, its natural consequences and things that go wrong, and most importantly, how to correct many of them.

For decades, most of what we knew about the diseases of aging was dismantled and disconnected "Spare Parts" full of possibilities and temptations, but his lack of "glue" a unifying central singularity. Now we have to stick – a hypothesis these cuts global weaving a whole cloth disconnected that is mechanically definable. We have gone from correlation to causation, better estimates of applications viable. Incredibly, our biggest murderers as as heart disease, cancer, diabetes type II, wasting neuromuscular / vascular and even aging itself is a single entity with many negative facets, each with unique characteristics. This even includes the extension of life span beyond human normal

Max. Of course, we do not know everything, however, just as you never know everything about nothing, but finally we enough about this to call a system. Once you have a system, you can plan smart. Before that, we are stuck with the "best estimates".

We provide a brief outline of the theory here, but this document is mainly devoted to the practical applications of this theory, "What can be done." These are the things that are implemented to prevent these diseases and to maximize the potential to live longer than Nature's plan originally built in you. You will be pleasantly surprised at how simple it can really be. Many of the complexities of the past disappear because much part of the "Voodoo" and the confusion disappears.

A central theory of diseases of aging biomedicine is that E = MC squared did for physics. Let the scales fall from our eyes, and allows us to see through the halls of mirrors in the window overlooking the garden understanding. These two authors have studied thousands of scientific papers over the past two decades, paying special consideration to the last six years, and again and again we find the overall metabolic theory make sense of our perplexities. Epiphany is a more refreshing, because a dark and winding road has become straight and true in the dappled sunlight. What had been obscured and is perfectly clear.

Scientific documents in recent years are much more interpretable within this framework unifying. Soon, these arrangements will be announced by the legions of scientists and shortly after, the world. This document and other documents published recently announced the arrival of this new era of extended youth and vitality.

Before I jumped into practical applications, we will have a short reading of the theory. Besides water and minerals, 95% of meat animals of all organisms, from unicellular organisms, sponges, worms, insects, mice and even humans, consists of four basic bio-chemicals: carbohydrates, fats, amino acids and nucleotides, which can be used

or as a fuel or construction material cell. That can be burned as fuel for tissue for energy or in combination to form large molecules that form the structures and functions of a new cell. The universal regulatory pathway, manipulates the flow of these four major components and the energy balance of the cell to control the maintenance of housekeeping functions in non-dividing cells and to provide energy and material flow in construction processes to create new cells. In the past, I knew a lot about the flow patterns, but not know how the component systems were managed. Now we know, and we are discovering how the regulatory pathway works to control the duration of our lives through their process of rejuvenation, regeneration and degenerative diseases.

The core sequence is called a regulatory pathway AMPK to terms of reference of PGC-1 alpha ROS SESN and back to AMPK, the feedback loop. Do not be afraid of the jargon of science, is a simple list of five elements. Just think of them as the names of five people who have not met yet, and are about to start learning. Writing this cycle of five points down in a notebook and refer to it as you read this article and to remain anchored in the discussion. A more in depth description is presented in "The Way Life Extension, Resveratrol, etc and Cancer Control: Duality mitochondrial biogenesis, the metabolic mechanism and Practical Applications, "which can be found through search engines under "Life Extension Bambeck Wolfson.

Caloric restriction (CR) is the "Gold standard" of life extension. CR activates AMPK to inhibit TOR and other elements of control in this way, all the way back to AMPK. In short, an up arrow next to the AMPK results in a down arrow next to everything else. He got the notebook? Installation of arrows now. In contrast, inhibition of AMPK shortens life, and all the arrows pointing in the opposite direction. Pretty easy, right? Well, yes and no, because the devil is in detail, and each component can be activated individually or in combination. To keep the notebook in hand. For example, medications such as metformin and rapamycin, nutraceuticals such as resveratrol, and hormones like growth hormone and thyroxine, which may act alone or in combination

in different parts of the road to mimic one or inconsistent with CR. Among other things, this pathway controls the building (neogenesis) and efficiency (ReGenesis) of mitochondria, oxygen with greater unity of the burning of fuel in all animal cells. Mitochondria are found between PGC-1 alpha and ROS. Cancer cells undergo disorders of mutations that alter the fuel does not burn oxygen in a process called glycolysis hyper-bound. New drugs are being found to disrupt these conditions, benefits and performance results. Therefore, as can be seen on the one hand, it is quite simple, but otherwise can be a bit hairy.

This should be enough for the reader to understand basically the practical applications section below. If you need more information to complement knowledge, please do not hesitate to consult the cited publication. And, my friends, let's take a look at some practical applications. Now, do not forget to drag the notebook with you. We do not want anyone to perish.

PRACTICAL APPLICATIONS: easy things you can do

One might regard this as part of the wild hypothesis of documents, but on the basis of the above results, the proposals could actually be more strong that many of the things health peppers from the grocery store cash registers. However, to remind everyone that there are doctors, and therefore, no license to practice medicine. It is not our intention to do so. Any use of the information contained therein is up to the reader. We specifically disclaim any liability arising directly or indirectly from the use or application of any information contained in any of these items. What we write here is speculation free of ideas involved in the counter phytonutrients and lifestyle options.

Recent longitudinal studies show that dietary sugar is killing us is stronger than saturated fat, protein or high, found in animal products. Diseases of aging such as diabetes, heart disease and

cancer kills the vast majority of us and too much sugar in the diet (extracellular) is a major cause and growing. However, AMPK previously described, TOR, PGC-1 alpha, ROS, SESN cycle performance shows that the relentless decline of the system-diseases of aging, in spite of sugar in the diet due to intracellular metabolic changes over time. In other words, despite the sugar prompted the creation of our lives since the beginning at birth, eventually we will kill but not eat it. This is "natural" aging, and the data clearly show that efforts are not natural supra-natural or should do to get the supra-natural or natural state called life extension beyond natural limits or is normally expected. Face it, calorie restriction (CR) is draconian and it is natural in the sense that, in nature, sometimes the food runs out. CR No body "naturally" itself in the presence of adequate food. Large doses of anti-oxidants or a hundred bottles of wine per day value of resveratrol is decidedly unnatural. Similarly, the restriction of amino acids in the form of a reduction of dietary methionine, appear to act in synergy as a CR mimetic. However, a diet seems too complex, limited and unnatural to be practical in a preliminary examination as this. Let's leave things the way for future consideration in a paper application for expansion later.

That said, the way things have been found to stand the test of time. For example, the Chinese have been taking resveratrol high Japanese bloody root extract called itadoli tea for thousands of years with beneficial results and claimed no effect known harmful except for some occasional intestinal discomfort, found mostly due to the emodin, an extract of cooperation, which certainly is not located in the modern concoctions. The remainder of this brief analysis is mainly devoted to some unnatural "natural" things people could do without live the life of a menagerie supplement the support of about anorexia with concomitant impairment of the muscles, wound healing, immune function, the fertility and others. The goal here is to force a default state for mitochondrial ReGenesis, which is the heart and soul of the life extension and inhibition induction of cancer cells and maintenance. Therefore, the argument completely avoid warnings schoolteacher widely used as "eating vegetables "," Take your

vitamins, "" regular exercise "," drink lots of water "," weight control "," not eating between meals, "" brush your teeth after every meal, "" do not eat anything that you can not fit in the mouth, "" do not swallow, if you can not pronounce i ',' holy cow, that sure is a big fish "and the other common-sense standard price that does not even to mention here.

It is difficult to determine the amount of resveratrol in the diet is and how much is regenic neogenic. There may be largely due its avoiding neogenic Tor, catabolic functions and antioxidants plus its average life expectancy increasing and the results of rejuvenation in the absence of induction of cancer or any increase in the length reduction of real life. Resveratrol also standard diet can be very strong because there regenic Regulation and appreciable AMPK, a reduction actual incidence of cancer, without an increase in apoptosis of cancer cells and not real life extension. However, mitochondrial biogenesis is observed much, but how much of this is becomes regenesis neogenesis is unknown because most researchers were aware of the difference.

Progressive Nutraceuticals supply companies recognize this and are actively seeking solutions. The essential problem is simple. When resveratrol eat, the more 90% of it is sulfonated and glucuronidated in the intestines and liver through the hepatic portal system, the provision soluble in water, while the aims for renal elimination of the urinary tract. Resveratrol free, without changing the diet is usually less than 2 uM during an hour and a half high blood plasma following intake phase. Resveratrol glucuronate and sulfate derivatized not to cross the membranes of interstitial cells and resveratrol on the cell-free microsomal fractions indicate that the interstitial cells and extracellular sulfatases glucuronidase have no overall impact. This can not be true at sites of inflammation, but everything you want body effect does not seem to be there. Although figures are not holding or rotation on the free intracellular resveratrol does not appear to accumulate over time. Experiments have shown that serum levels of soluble free resveratrol in the range of 20 uM final impact of the route of CR / AMPK. For example,

DMSO solubilized resveratrol, when injected into mice, causes all the desired AMPK and downstream effects in brain tissue.

As mentioned above, suppliers of nutraceuticals are being very clever in their attempts to obtain serum concentrations of resveratrol to the range CR mimetic. A sample of providers, graphically, how micronization resveratrol resveratrol increases dramatically free up to and beyond the minimum required scope activation of AMPK. Other vendors are creating encapsulated formats solubilized and released over time. A supplier offers sublingual tablets. Resveratrol mixed with synergists such as quercetin and coenzyme Q, are also offered. We look forward to the time the serum-based data, and indeed its intracellular AMPK data regulation.

Here is a quick and dirty home remedy. Can dissolve up to approximately 500 mg of resveratrol in a shot alcohol or 86 proof schnaaps taste for the more faint of heart. Solubility depends mainly on alcohol content, so it must be a glass of wine, but it may take a while to dissolve. In addition, the lower volume, better it is for non-intestinal absorption. Taking a sip, revolving around his mouth for a minute before swallowing, relax and enjoy. Dissolution is what we might call the technical nanonization. It has been shown to improve oral and digestive absorption up to 800% above methods of diet, and not increase the load a kidney metabolite apex. However, many health gurus out there tell us that 10-20 grams of ethanol per day is good for us.

Then there's the stretch (or distortion) of his imagination beyond Pluto's orbit, plan. Humans have circadian cycles daily and monthly spots for a reason. Anyone who has read about the known circadian rhythm of melatonin what we are talking about. The fact that human females have a cycle length of the lunar cycle of receptivity, and in small groups, very close, the cycle as a whole, is no accident. The cycle based on the season was replaced by

the lunar cycle, because the conditions made it possible. What made it possible, is consulted? We never thought that going to ask.

The strength of evolutionary mutation is the primary engine, but it is accidental, generational and often hopeless, the selective advantage to rare. However, winners to support the survival of the population as generations of adaptation. The advantage of selecting a switch from one season to the lunar cycle must have been powerful, simply because he was forced into existence. Consider the following. Over 99% of the last two million years or less, human evolution, has been dedicated to slow and steady conversion of the collection, the collection of treasure hunters and gatherers, while the remaining less 1% is called civilization. Having an excellent vision in 3-D color, but a poor night vision, light the night of the full moon became a great advantage as I went to purchase food and broader geographic easy loot. Being bipedal and have prehensile dexterity in an ecosystem by reducing Dryas were great evolutionary pre-adaptation and the opportunity to address the drivers of the death of proto-humans.

This switch power dynamic created food-nutrition super moon for several days a week, followed by a month remaining to be caught in the standard rate. This tuning a monthly cycle high, disordered eating, which caused the elevated body fat that conveniently could support the growth of endometrium and fertility, two weeks after the full moon at night pitch black the new moon. Since no one looks bad in the dark, no alcohol is still invented, and also to be nothing more to do than stumble around like idiots blind, a party nutritional status was made in heaven. In addition, sexual glue is the social glue. This was already operating in the context of a proto-hominid brain noisy large creature, with its niche Green pushing a move to further brain growth, symbolic representation such as language and tool kit simply pre-social civilization population figures expecting big enough to invent great things, such as cities, war and jacuzzis. Therefore, the African stage was set, and fortunately for us, the four acts played before us, as evidenced by the genetic evidence, almost extinct.

This pattern also reflects a natural cycle of nutrients boosted monthly AMPK activity and a low and high regular neogenesis and regeneration cycle, which may have helped us become the oldest primates. The long delivery period, the endless stretch of time from birth to sexual maturity and the creation of history, the need of elders to pass on all that the accumulation of great minds of the next generation group incomprehensible that seem to emerge for the first time in memory with each new generation, may have contributed to helping this mixture of lengthening life. In the context of this work, that is, if there is still some sense, this long encourage speculative candidates just come to be followed with a format of circadian recipe / mole.

The arrival of the concentration of resveratrol commercially available high bioavilable open the door to possibilities that really bring the troops home. A full dose, it would bias the system toward certain mimesis CR regenesis driven mitochondrial AMPK, whereas a full dose tenth, which would bias the system towards the goal-neogenic mimicry is described in detail before. From neogenesis takes several days to complete, while ReGenesis is much faster, a plan of the circadian cycle / lunar forces the system to values regenesis default long to prolong life, it could be something like this: Resveratrol under neogenic dose could be coordinated with antioxidants, the burden of dietary nutrients and / or exercise of power based on five to seven days or so, then followed by high doses of resveratrol coordinated with the avoidance of foods every day between dinner and breakfast and / or the use of high oxygen tolerance for exercise before breakfast in a longer time frame, for example about three weeks, to enhance mitochondrial efficiency, cleaning the mobile home and away from glucose to fat burning. Here is something for everyone. Lounge Lizards can reap the benefits the pattern of phytonutrients unique effect, while the restless spirits of us may increase the effects of dieting and exercise. Either Thus, organs and other tissues of cardiovascular and skeletal muscle can become larger on benefits of resveratrol. Numerous daily variations, weekly and monthly reports on the subject could anticipate. A plan could be to include a meal

day because of chronic defect in the morning to ReGenesis and / or exercise to help with debt ReGenesis glucose nutrients and / or a CR mimetic to activate AMPK life extension loop.

A study in rats very interesting intermittent CR has the world of RC hobbyists in your ear. Using alternate days of ad libitum food supply and total fasting in rats Long-term results in any CR, like rats to make it up for the party between the days of fasting, while the extension to end of life comparable to the CR. This jives more or less with the downregulation of PGC-1 alpha in turn regenesis time frame. In fact, this study is the first real test since the extension CR of life can not go without it. This also jives with our idea that at least partial neogenesis followed by regeneration, it will not hurt extension life, and you can avoid the risks of poverty and disadvantage of a true RC.

An interesting question arises here. Since CR is a life ReGenesis long-term holding extension pattern, the time is right? For this, we mean: Once the mitochondria become efficient, how much time are efficient before they need to be efficient restimulated again? In other words, how many holidays you can "get away with it" before each day of fasting? If ReGenesis is good for a week, then one day a week fast is a small price to pay. Not only that, if 18 hours of fasting works and 24, then all you do is miss breakfast once a week. Can be supplemented with a low or high dose resveratrol regimen emphasizing effect?

Need experiments and we need them sooner rather than later. But the rats live five years or more, and rats are not people, (Unlike, often times, the reverse). On metformin is against more than a decade away, if any, and rapamycin is too dangerous to be street legal at any time, dimension or reality. Metformin, when used with growth hormone to the mechanical strength of the system to switch between neogenesis and regenesis ultimately become the greatest achievement of more anti-aging rejuvenation of all time. This truth can cause

The cells behave more like they do in the juvenile stage. Time, dose and the required proof of such a scenario would be critical. This is playing with some of the truly great mojo here and it would be illegal without a prescription under the care of a physician. Only people, at least, early middle age, for example last thirty years, could participate in this program, safely.

Fortunately, today, we resveratrol, which is freely available and we know enough about CR and mitochondrial neogenesis and regeneration, to get answers instantly, and in humans rather than rats. Volunteers and tissue biopsies by measuring CR AMPK activity and mitochondrial enzyme status of biogenic vs Krebs cycle of cytochrome content, allow us to track the status of the system over time. The system is sufficiently well defined, since the meanings of these tests indicate causality and correlation. A wide range of experiments could be carried out quickly, and could signal that the times are optimal conditions and regimes, whether there are down sides and what other elements could be included. Ideally, we can find a calendar of CR mimetic dose of resveratrol, a mimetic or a mixture of best synergistic components that require no lifestyle changes outside the normal practices health wise … except for the magic pill, of course.

EPILOGUE

About a week later completing the first draft of the section of practical applications, we read in the newspaper that exercise physiologists had discovered that "hydrates carbon load, "in his health, was well below the fasting before and during a workout. What of the" carbo-loading "can work if you are training for the Tour de France, but not for the average Joe. Fasting does not burn oxygen causes sugar in return for more oxygen to burn fat and white muscle inefficient change in red muscle efficiently, simultaneously with beneficial cardiovascular effects, weight loss and

reduction in diabetes causes insulin resistance. Curious, we hypothesized that starvation induced by adrenaline was setting changes. Perhaps there is a better hypothesis, and is easy we guess what it is. Several months after we published our first article on the metabolism of cancer, which describes a scenario of thirty years, researchers announced a "newly discovered" stop cancer growth hyperglycolysis blocking therapy concept of "awakening" (his words) ReGenesis mitochondrial (our words). Then about a fumble for the concept of a mechanism. We're pretty firm in what we believe the mechanism is. Diabetic lung cancer victims to live longer with metformin, but researchers do not make the connection CR. Resveratrol diet with exercise increases muscle mitochondrial volume more than exercise alone or resveratrol alone and reduces ventricular hypertrophy. What is the connection? Measurements of mitochondrial biogenesis sometimes show one thing and show sometimes another, and scientists are confused because they do not know the difference between neogenesis and ReGenesis. The arguments arise in the capo on whether pharmaceutical companies Resveratrol is a CR mimetic, or no, because researchers have not separated CR meta-imitation of imitation CR. Wherever we look, we see examples like this, where specialists comprise one or two trees for the forest good and so bad that the conclusions to be almost strange, contradictory and unreal. Many scientists in the fields we visited would not be so surprised or shocked if there was only one global unifying hypothesis for their consistent results. We have a theory, and all these questions make sense to us. Prudent application of a theory can have impressive impact on the nation's medical bill and the total number years that are added to human life, in the first case, is measured in billions of dollars, and in the second case, measured in billions of years. This is a big … really big things.

Gregory S. Bambeck Ph.D. e-mail: gregorybambeck@yahoo.com

Michael Wolfson JD, MBA e-mail: mwolfson@stanfordalumni.org

Copyright © Gregory Bambeck and Michael Wolfson June 19, 2010.

About the Author

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